NFATc1 Induction in Peripheral T and B Lymphocytes

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NFATc1 induction in peripheral T and B lymphocytes.

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In lymphocytes, immune receptor signals induce the rapid nuclear translocation of preformed cytosolic NFAT proteins. Along with co-stimulatory signals, persistent immune receptor signals lead to high levels of NFATc1/αA, a short NFATc1 isoform, in effector lymphocytes. Whereas NFATc1 is not expressed in plasma cells, in germinal centers numerous centrocytic B cells express nuclear NFATc1/αA. Wh...

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ژورنال

عنوان ژورنال: The Journal of Immunology

سال: 2013

ISSN: 0022-1767,1550-6606

DOI: 10.4049/jimmunol.1201591